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Goiter in Asturias

 
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Marta Elena Díaz García
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Joined: 07 Sep 2003
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Location: Molleda. Corvera de Asturias

PostPosted: Fri Aug 04, 2017 2:52 pm    Post subject: Goiter in Asturias Reply with quote

For years, the endemic goiter was a problem in Asturias, particularly in isolated mountainous places and due to an iodine poor diet, with no fish and to the iodine poor mountain water.

Iodine prophylaxis with salt was effective to diminish the endemic goiter in the area.

The picture included in this post is from the cover of the book "El bocio endémico en Asturias. 10 años de profilaxis con sal yodada" by Elías Delgado Álvarez and F. José Díaz Cadórniga.

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Art
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Joined: 17 Feb 2003
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Location: Maryland

PostPosted: Sun Aug 06, 2017 1:47 am    Post subject: Reply with quote

Thanks, Marta, I didn't know that Asturians had experience this problem. It has appeared in my own family. I wondered if there is a genetic propensity to goiter and located several articles, such as this one:
https://www.ncbi.nlm.nih.gov/pubmed/16054835
That article reported a a strong genetic component in euthyroid familial goiter.
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Marta Elena Díaz García
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Location: Molleda. Corvera de Asturias

PostPosted: Sun Aug 06, 2017 2:22 pm    Post subject: Reply with quote

Hi, Art:

I don't know if there is a genetic propensity, but I know that there are different types of goiter. In the particular case of endemic goiter, it is the result of an iodine poor diet.

The genetic goiter seems to be due to an enzymatic defect that results in the lack of iodation of the hormone tyroxine.

There are some substances that induce goiter (an excess of iodine also results in goiter). Some pharmaceuticals are among those substances. For example, the best known is the amiodarone (antiarrhythmic medication used to treat ventricular tachycardia or ventricular fibrillation) that contains high amounts of iodine.

I could not open the link you provided.
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Bob
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PostPosted: Sun Aug 06, 2017 6:45 pm    Post subject: Reply with quote

The genetic and environmental interactions of goiter can be complex. I fixed Art's link - it had a trailing "]article" that caused it not to work. Given the historic difficulty of transporting seafood to the mountainous regions of Asturias, I'm not surprised to find goiter there. Goiter was also common n some locations in the EEUU that are far from the sea.
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Art
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PostPosted: Mon Aug 07, 2017 1:20 am    Post subject: Reply with quote

Thanks for the help, Bob!

Marta, I hadn't thought about how medications could affect goiter. It makes sense.
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Bob
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PostPosted: Mon Aug 07, 2017 8:10 am    Post subject: Reply with quote

Levothyroxine is a standard treatment for hypothyroidism. It can be used to treat goiter because it lowers TSH (thyroid stimulating hormone).
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Art
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Location: Maryland

PostPosted: Wed Aug 16, 2017 2:55 pm    Post subject: Reply with quote

This interesting article in the NY Times explains why some regions have more problems with iodine deficiency.
https://www.nytimes.com/2017/07/21/well/eat/should-we-be-buying-iodized-salt.html
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Bob
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PostPosted: Wed Aug 16, 2017 4:45 pm    Post subject: Reply with quote

Pregnancy can result in iodine deficiency because the bodies of the fetus and mother interact to provide the fetus with whatever it needs for growth and development. The mother's bones will give up calcium too.
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Marta Elena Díaz García
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Joined: 07 Sep 2003
Posts: 362
Location: Molleda. Corvera de Asturias

PostPosted: Fri Aug 18, 2017 2:25 pm    Post subject: Reply with quote

Yes, there are many recommendations about to take iodine supplements not only during pregnancy but also while breastfeeding.
In iodine-deficient regions it seems that supplementation of breastfeeding-mothers with iodine is more effective than direct supplementation of the infant in order to reduce infant iodine deficiency.
Anyway, it seems that the amount of iodine that must be take needs to be carefully controlled, otherwise other problems may arise.
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